RAD51D and PRDM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAD51D	PRDM6
Description		RAD51 paralog D	PR/SET domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus
	Molecular Function	Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding	Protein Binding Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Reciprocal Meiotic Recombination Interstrand Cross-link Repair Strand Invasion Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Histone Methylation Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS			Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 26390057 27841878 27618447 30578418)
Interacting Genes		49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7	70 interacting genes: ABI2 AGXT AHCYL1 ANKS1A AQP1 ARID5A ATPAF2 ATXN7L2 BAG3 BANF2 BANP C1orf109 CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM214B FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A STK16 TCAF1 TEKT4 TLE5 TRIM14 TRMT12 TSGA10 TSGA10IP TSSK3 TTC23 UBASH3A USP54 ZFYVE26
Entrez ID		5892	93166
HPRD ID		04261	19698
Ensembl ID		ENSG00000185379	ENSG00000061455
Uniprot IDs		O75771	Q9NQX0
PDB IDs		2KZ3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?