RAC1 and METAP2

Number of citations of the paper that reports this interaction (PubMedID 7738010)
12

Data Source:
HPRD (in vitro)

		RAC1	METAP2
Description		Rac family small GTPase 1	methionyl aminopeptidase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Membrane Lamellipodium Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Cell Projection Dendritic Spine Recycling Endosome Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding Enzyme Binding Protein Kinase Binding Small GTPase Binding Thioesterase Binding Histone Deacetylase Binding Protein-containing Complex Binding Rho GDP-dissociation Inhibitor Binding ATPase Binding	RNA Binding Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Mast Cell Chemotaxis Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response Actin Filament Organization Cell Adhesion Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Motor Neuron Axon Guidance Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Ruffle Organization Negative Regulation Of Interleukin-23 Production Regulation Of Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Engulfment Of Apoptotic Cell Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Positive Regulation Of DNA Replication Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Cell Motility Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Cellular Response To Mechanical Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Ruffle Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Migration	Protein Processing Peptidyl-methionine Modification N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Factors involved in megakaryocyte development and platelet production	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Methionine Nitroxoline 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide tert-butanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin PPI-2458 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID TNP-470
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Coronary artery disease ( 29212778) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Red cell distribution width ( 27863252)	Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Reticulocyte count ( 32888494)
Interacting Genes		182 interacting genes: ACTA1 ACTB AGAP1 AGAP2 AKT1 ARAP1 ARAP2 ARFIP2 ARHGAP1 ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP44 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT COG5 CORO1C CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DNMBP DOCK1 DOCK2 DOCK3 DOCK7 DOCK8 DVL1 DVL2 EIF2AK2 ENAH FAM13A FAM13B FGD5 FHOD1 FLNA FMN2 FMNL1 GMIP GRN HACD3 HACE1 HDAC7 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KPNA4 KPNA6 KRT40 KTN1 LATS1 LRP2 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2 MCF2L MCM3AP MDFI METAP2 MT-CO3 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 NR2C2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6A PARD6B PARD6G PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG1 PLEKHG2 PLEKHG6 PLXNB1 PPP2R2B PREX1 PREX2 PRKCA PRKCD PRKCI PRKN PRMT6 PTK2 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 SNX31 SRGAP1 SRGAP3 STAT1 STAT3 STAU1 SYDE2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UBC UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1	14 interacting genes: APP CALM1 CDC42 EIF2AK2 EIF2S3 FBXL17 HMGA1 MAPK1 MAPK3 OGT PJA1 RAC1 S100A4 YWHAE
Entrez ID		5879	10988
HPRD ID		03627	03522
Ensembl ID		ENSG00000136238	ENSG00000111142
Uniprot IDs		A4D2P0 A4D2P1 P63000	A0A140VJE3 F8VQZ7 P50579
PDB IDs		1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 6AGP 6BC1 6TGC 6X1G 7AJK	1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ 7A12 7A13 7A14 7A15 7A16
Enriched GO Terms of Interacting Partners?
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