QARS1 and ACTN2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
170

Data Source:
BioGRID (two hybrid)

		QARS1	ACTN2
Description		glutaminyl-tRNA synthetase 1	actinin alpha 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Cell Junction Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Nuclear Receptor Coactivator Activity Titin Binding Identical Protein Binding Transmembrane Transporter Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Muscle Contraction Cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Uncapping Muscle Cell Development Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		157 interacting genes: ACTN2 ANXA7 APP ASL B9D2 BIRC7 CALCOCO2 CCDC33 CDK4 CDKN1A CLTC COG6 CPNE3 CTBP2 DISC1 DNM2 DPPA4 DTX2 DUSP11 EDC3 EFHC2 ESS2 FAM118B FAM161A FAM83A GADD45A GPBP1 GSK3B GSTZ1 H2AX HES7 HMG20A HOXA1 IK IKZF1 IRF1 KCNE3 KLC3 KRT36 LAMTOR3 LGALS9B LGALS9C LNX1 LZTS1 LZTS2 MAP3K5 MCCD1 MESD MID2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NAB2 NEBL NFKBID NLGN3 NOXA1 PICK1 PIK3R3 PIN1 PPP1R32 PRDM6 PRRC2A PTPN21 RARS1 REL RNF11 SF3B4 SHLD1 SLA SMAD9 SMN1 SORBS3 SP7 SPATC1L SPDYE4 SPRED2 STK3 TADA2A TCF12 TGM7 TK1 TLE5 TOPAZ1 TRAF2 TRAF4 TRIM27 TRIM35 TRIP13 TSC22D1 TTR USHBP1 VPS37B XIAP ZMYND12 ZRANB1	112 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKAP8L AKTIP ANG ANGPTL7 ARX ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CACNA1C CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 FXR1 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 ODF3B PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SHANK3 SMARCA2 SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TSC1 TSC2 TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID		5859	88
HPRD ID		07223	00019
Ensembl ID		ENSG00000172053	ENSG00000077522
Uniprot IDs		B7Z840 P47897	P35609 Q59FD9
PDB IDs		4R3Z 4YE6 4YE8 4YE9	1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT 6TS3
Enriched GO Terms of Interacting Partners?
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