PZP and MMP2

Number of citations of the paper that reports this interaction (PubMedID 9344465)
7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PZP	MMP2
Description		PZP alpha-2-macroglobulin like	matrix metallopeptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Female Pregnancy Negative Regulation Of Endopeptidase Activity	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin
Diseases
GWAS		Blood protein levels ( 29875488) Depression in smokers ( 30219690) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 32154731) Myopia ( 27182965) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2	39 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		5858	4313
HPRD ID		07178	00386
Ensembl ID		ENSG00000126838	ENSG00000087245
Uniprot IDs			A0A024R6R4 P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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