PURB and PURA

Number of citations of the paper that reports this interaction (PubMedID 10318844)
31

Data Source:
HPRD (in vitro, in vivo)

		PURB	PURA
Description		purine rich element binding protein B	purine rich element binding protein A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromosome, Telomeric Region Nucleus Dendrite Cytoplasm Neuronal Cell Body Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Cell Differentiation Regulation Of Myeloid Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Unwinding Involved In DNA Replication DNA Replication Initiation Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Lymphocyte Proliferation Epithelial Cell Proliferation Dendritic Transport Of Messenger Ribonucleoprotein Complex
Pathways
Drugs
Diseases
GWAS		Platelet count ( 27863252)	Body mass index ( 26426971)
Interacting Genes		22 interacting genes: AP1M1 CSNK2A1 IL7R LNX1 MBD2 MIR128-1 MIR128-2 MIR25 MIR29C MIR31 MIR34B MIR363 MIR7-1 MIR7-3 MIR9-2 MIRLET7A3 MIRLET7G MIRLET7I NABP1 PCDHB14 PURA ZNF497	58 interacting genes: ADAP1 CCNT1 CDK5 E2F1 IL7R MIR1-1 MIR106B MIR122 MIR128-1 MIR128-2 MIR140 MIR143 MIR155 MIR15B MIR16-2 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR9-2 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PTEN PURB RAF1 RB1 SP1 YBX1
Entrez ID		5814	5813
HPRD ID		12325	02721
Ensembl ID		ENSG00000146676	ENSG00000185129
Uniprot IDs		Q96QR8	Q00577
PDB IDs
Enriched GO Terms of Interacting Partners?
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