PTPN3 and TFAP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PTPN3	TFAP4
Description		protein tyrosine phosphatase non-receptor type 3	transcription factor AP-4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane	Chromatin Nucleus Nucleoplasm Mitochondrion Transcription Repressor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Protein-containing Complex Assembly Cellular Response To Dexamethasone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)	Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 26635082) Platelet count ( 32888494) Prostate-specific antigen levels ( 28139693) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10	12 interacting genes: AJUBA EXOSC8 GOLGA2 INCA1 MCRS1 PDE9A PTPN3 SFMBT2 TEKT4 TRAF1 TRAF4 VMAC
Entrez ID		5774	7023
HPRD ID		06767	11795
Ensembl ID		ENSG00000070159	ENSG00000090447
Uniprot IDs		B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3	Q01664
PDB IDs		2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36
Enriched GO Terms of Interacting Partners?
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