PTN and PTPRS

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	PTPRS
Description		pleiotrophin	protein tyrosine phosphatase receptor type S
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Neuromuscular Junction Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Postsynapse	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Chondroitin Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Vascular Endothelial Growth Factor Binding Syndecan Binding Heparan Sulfate Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Liver Development Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Heart Development Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Response To Xenobiotic Stimulus Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Response To Activity Negative Regulation Of Angiogenesis Spinal Cord Development Cerebellum Development Thalamus Development Bone Mineralization Lung Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Response To Estradiol Response To Progesterone Cellular Response To UV Cellular Response To Platelet-derived Growth Factor Stimulus Tissue Regeneration Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Endothelial Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Membrane Potential Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Retinal Rod Cell Differentiation Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Cellular Response To Vitamin D Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Response To Kainic Acid Rod Bipolar Cell Differentiation Response To Ciliary Neurotrophic Factor Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Neuromuscular Junction Development Response To Nerve Growth Factor Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion
Pathways		Signaling by ALK Signaling by ALK	ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)
Drugs			Alendronic acid Etidronic acid
Diseases
GWAS		Aluminium levels ( 26025379) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)	Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)
Interacting Genes		98 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2	27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A
Entrez ID		5764	5802
HPRD ID		01199	03344
Ensembl ID		ENSG00000105894	ENSG00000105426
Uniprot IDs		A0A024R778 P21246	Q13332 Q59FX6 Q8NHS7
PDB IDs		2N6F	2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?
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