NYAP2 and CYFIP1

Number of citations of the paper that reports this interaction (PubMedID 21946561)
21

Data Source:
BioGRID (pull down)

		NYAP2	CYFIP1
Description		neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	cytoplasmic FMR1 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component		Ruffle Extracellular Region Cytosol MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Filopodium Tip Secretory Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Growth Cone Axonal Growth Cone Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Central Region Of Growth Cone Peripheral Region Of Growth Cone Tertiary Granule Lumen
	Molecular Function	Protein Binding	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding Translation Regulator Activity Actin Filament Binding
	Biological Process	Phosphatidylinositol 3-kinase Signaling Neuron Projection Morphogenesis	Cell Morphogenesis Regulation Of Translation Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Ruffle Organization Regulation Of Myelination Cellular Response To Insulin Stimulus Positive Regulation Of Axon Extension Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Electrical Stimulus Dendrite Extension Modification Of Synaptic Structure Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Aspartate aminotransferase levels ( 33547301) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) LDL cholesterol levels in HIV infection ( 33109212) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Triglyceride levels in HIV infection ( 33109212) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378) Walking pace ( 33128006)	Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)
Interacting Genes		6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NUP98 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		57624	23191
HPRD ID		13867	05890
Ensembl ID		ENSG00000144460	ENSG00000273749
Uniprot IDs		Q9P242	Q7L576
PDB IDs			3P8C 4N78
Enriched GO Terms of Interacting Partners?
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