PTMA and H2AC14

Number of citations of the paper that reports this interaction (PubMedID 8814229)
11

Data Source:
HPRD (in vitro)

		PTMA	H2AC14
Description		prothymosin alpha	H2A clustered histone 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Apoptotic Process
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		44 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 GSK3A H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 PTPN2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP TERT VIPR1 ZDHHC17	1 interacting genes: PTMA
Entrez ID		5757	8331
HPRD ID		01778	09102
Ensembl ID		ENSG00000187514	ENSG00000276368
Uniprot IDs		P06454 Q53S24	Q99878
PDB IDs		2L9I 2MNQ
Enriched GO Terms of Interacting Partners?
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