INTS2 and DEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		INTS2	DEF6
Description		integrator complex subunit 2	DEF6 guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Integral Component Of Membrane Nuclear Membrane Integrator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	SnRNA Processing SnRNA 3'-end Processing	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CCDC57 DEF6 KDM1A NCK2 SUV39H1	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		57508	50619
HPRD ID		11137	10869
Ensembl ID		ENSG00000108506	ENSG00000023892
Uniprot IDs		A0A024QZ48 J3KMZ7 Q9H0H0	Q9H4E7
PDB IDs		7CUN
Enriched GO Terms of Interacting Partners?
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