PTK2 and PTPN11

Number of citations of the paper that reports this interaction (PubMedID 10655584)
181

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PTK2	PTPN11
Description		protein tyrosine kinase 2	protein tyrosine phosphatase non-receptor type 11
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Dendritic Spine Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Protein-containing Complex Plasma Membrane Raft
	Molecular Function	Actin Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Receptor Tyrosine Kinase Binding D1 Dopamine Receptor Binding Phospholipase Binding Insulin Receptor Substrate Binding Cadherin Binding Cell Adhesion Molecule Binding Peptide Hormone Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	Angiogenesis Placenta Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Detection Of Muscle Stretch Netrin-activated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Growth Hormone Receptor Signaling Pathway Positive Regulation Of Wound Healing Positive Regulation Of Macrophage Proliferation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis	DNA Damage Checkpoint Signaling Triglyceride Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axonogenesis Brain Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cerebellar Cortex Formation Platelet Formation T Cell Costimulation Negative Regulation Of Chondrocyte Differentiation Microvillus Organization Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Abortive Mitotic Cell Cycle Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Cell Adhesion Mediated By Integrin Multicellular Organism Growth Organ Growth Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Atrioventricular Canal Development ERBB Signaling Pathway Hormone Metabolic Process Glucose Homeostasis Regulation Of Protein-containing Complex Assembly Positive Regulation Of Ossification Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Regulation Of Protein Export From Nucleus Positive Regulation Of Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Multicellular Organismal Reproductive Process Smooth Muscle Cell Proliferation Genitalia Development Inner Ear Development Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Negative Regulation Of Growth Hormone Secretion Face Morphogenesis Regulation Of Type I Interferon-mediated Signaling Pathway Intestinal Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Angiotensin Cellular Response To Insulin-like Growth Factor Stimulus
Pathways		Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Signal regulatory protein family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis	Interleukin-6 signaling PI3K Cascade MAPK3 (ERK1) activation MAPK1 (ERK2) activation GPVI-mediated activation cascade Prolactin receptor signaling PIP3 activates AKT signaling Spry regulation of FGF signaling Signaling by SCF-KIT GAB1 signalosome Downstream signal transduction PECAM1 interactions Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer Signaling by Leptin Costimulation by the CD28 family CTLA4 inhibitory signaling PD-1 signaling Signal regulatory protein family interactions Netrin mediated repulsion signals Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of IFNG signaling RET signaling Interleukin-20 family signaling MET activates PTPN11 Regulation of RUNX1 Expression and Activity Interleukin-37 signaling Activated NTRK2 signals through FRS2 and FRS3 Interferon alpha/beta signaling Regulation of IFNA signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants
Drugs		Endostatin 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE Fostamatinib	Dodecyltrimethylammonium
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30224653) LDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 27863252) Mood instability ( 31168069) Multisite chronic pain ( 33830993) Nickel levels ( 26025379) PR interval ( 32439900) Red cell distribution width ( 32888494) Response to interferon beta therapy ( 21502966) Smoking status (ever vs never smokers) ( 30643258)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood pressure ( 21572416) Body mass index ( 26426971) Diastolic blood pressure ( 26390057) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Glycated hemoglobin levels ( 34059833) HDL cholesterol levels ( 32203549) Hematological parameters ( 19820697) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) Low HDL-cholesterol levels ( 31006500) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Peripheral artery disease ( 31285632) Platelet count ( 22139419 32888494) Reaction time ( 29844566) Response to alcohol consumption (flushing response) ( 29460428) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Systolic blood pressure ( 26390057 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 17554300) Urate levels ( 23263486) Waist-to-hip ratio adjusted for BMI ( 34054925)
Interacting Genes		114 interacting genes: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 DOK4 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNB1 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PIK3R3 PKD1 PLCG1 PPP1CB PTEN PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SH2D1A SH2D1B SHC1 SOCS1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TNS3 TP53 TRIM15 TRIO TRIP6 TSC2 VCL YES1 ZFYVE21 ZNF331	173 interacting genes: AATK ACTN4 AKT1 AR ARHGAP1 AXL BCR BDKRB2 BEX1 BEX2 BLZF1 BRAP BTLA CALR CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTDSP1 CTLA4 CXCR4 DAB1 DDR1 DMRTC1 EGFR EPHA1 EPHA2 EPOR ERBB2 ERBB3 ERBB4 FAM71E1 FBXW7 FCGR1B FCGR2B FCRL3 FGFR2 FGFR4 FLT1 FLT3 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GMNN GOLGA2 GRB2 GRIN2B GTF2A2 HIP1R HNRNPU HSP90B1 HSPA5 HSPA9 HSPD1 IFNAR1 IFNGR1 IGF1R IL4R IL6ST ILK INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 LINC01558 LINC02907 LNX1 LRP1 MAP3K4 MAP3K5 MAPK3 MAPT MET MPIG6B MPL MPZL1 MS4A2 MVK MVP NCOR2 NEB NEDD9 NOX4 NRG3 NSUN5 NSUN5P2 NTRK1 NTRK2 ORMDL3 P2RX7 PAG1 PDGFRA PDGFRB PECAM1 PIK3CA PIK3CG PIK3R1 PILRA PILRB PLCG1 PNCK POU2AF1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTK7 PTPN6 PXN RANGRF RCOR3 RET ROR2 ROS1 RPIA SELE SERF2 SERPINF1 SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SLC38A1 SLN SOCS3 SOS1 SPRY2 SRC SRSF10 STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TLK1 TNFRSF1A TREML1 TRIM32 TRMT2B TSC2 TXNIP
Entrez ID		5747	5781
HPRD ID		02859	01470
Ensembl ID		ENSG00000169398	ENSG00000179295
Uniprot IDs		Q05397 Q59GM6 Q59GN8 Q658W2	Q06124
PDB IDs		1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S 6I8Z 6LES 6PW8 6YOJ 6YQ1 6YR9 6YT6 6YVS 6YVY 6YXV	2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI 4OHL 4PVG 4QSY 4RDD 5BK8 5DF6 5EHP 5EHR 5I6V 5IBM 5IBS 5X7B 5X94 5XZR 6ATD 6BMR 6BMU 6BMV 6BMW 6BMX 6BMY 6BN5 6CMP 6CMQ 6CMR 6CMS 6CRF 6CRG 6IHZ 6MD7 6MD9 6MDA 6MDB 6MDC 6MDD 6R5G 7JVM 7JVN
Enriched GO Terms of Interacting Partners?
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