DSCAML1 and PLCL2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
HPRD (two hybrid)

		DSCAML1	PLCL2
Description		DS cell adhesion molecule like 1	phospholipase C like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Axon Synapse	Cytoplasm
	Molecular Function	Protein Homodimerization Activity Cell-cell Adhesion Mediator Activity	Phosphatidylinositol Phospholipase C Activity Protein Binding GABA Receptor Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Cell Fate Determination Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axonogenesis Axon Guidance Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance	B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Lipid Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Regulation Of Peptidyl-serine Phosphorylation Phosphatidylinositol-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Receptor Binding
Pathways		DSCAM interactions
Drugs
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lipoprotein (a) - cholesterol levels ( 25575512) Menarche (age at onset) ( 23599027) Myopia ( 27182965) Putamen volume ( 29147026) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 28548082) Triglycerides ( 19074352 30275531) Very low density lipoprotein cholesterol levels ( 28548082)	Anxiety ( 33859377) Asthma ( 32296059) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Cognitive ability (MTAG) ( 29186694) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Intelligence ( 28530673) Lung cancer ( 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mood instability ( 31168069) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Myocardial infarction ( 24916648) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neurociticism ( 29500382) Primary biliary cholangitis ( 21399635 26394269) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Smoking initiation ( 33082346) Sum eosinophil basophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023)
Interacting Genes		3 interacting genes: MAGI2 MAGI3 PLCL2	2 interacting genes: DSCAML1 PPP1CA
Entrez ID		57453	23228
HPRD ID		10921	07147
Ensembl ID		ENSG00000177103	ENSG00000154822
Uniprot IDs		A0A384DVL8 Q8TD84	Q9UPR0
PDB IDs		1VA9
Enriched GO Terms of Interacting Partners?
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