PLEKHG5 and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHG5	AHCYL1
Description		pleckstrin homology and RhoGEF domain containing G5	adenosylhomocysteinase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Lamellipodium Endocytic Vesicle Axon Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding
	Biological Process	Rho Protein Signal Transduction Endothelial Cell Chemotaxis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Endothelial Cell Migration Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RND3 GTPase cycle RND1 GTPase cycle	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Multiple sclerosis ( 24076602) QT interval ( 19305408)	Height ( 31562340)
Interacting Genes		1 interacting genes: AHCYL1	25 interacting genes: BID CDKN2C DACH1 GEM HBQ1 HEXIM2 HGS HSPA6 ITPR1 JOSD2 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165
Entrez ID		57449	10768
HPRD ID		11104	07613
Ensembl ID		ENSG00000171680	ENSG00000168710
Uniprot IDs		O94827	A0A024R0A8 O43865
PDB IDs			3MTG
Enriched GO Terms of Interacting Partners?
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