CBX8 and PNMA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CBX8	PNMA1
Description		chromobox 8	PNMA family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		89 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-4 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RPGRIP1 RPTOR SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 TXNIP UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1	169 interacting genes: ABHD17A AGTR1 ANKRD36BP1 APTX ARHGEF6 ARID5A ASMTL ATP5PO ATP6V1G1 ATXN7 BEX2 BYSL C1orf109 C21orf58 C8orf33 CARHSP1 CBX8 CCDC146 CCDC187 CCDC198 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CHIC2 CHMP2B CNNM3 COX5B CTNNA3 DAXX DCTN4 EAF2 EHHADH ENKD1 FAM107A FAM110A FAM161A FAM161B FBF1 FBXL18 FEM1C FMNL2 FOXD4L1 FOXD4L3 FXR1 FXR2 GADD45GIP1 GATA1 GEM GPANK1 GPR25 GRAP2 GTPBP10 HAPLN2 HCK HDAC4 HGS HNRNPLL HOXB9 IGFN1 INO80B IVD KANSL1 KAT2B LAGE3 LENG1 LIN37 LMO3 LNX1 LSM2 MAB21L2 MACIR MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 MYO15B MYOZ1 NIF3L1 NPBWR2 NSMF NTAQ1 NUDT16L1 PARD3 PARD6B PCGF6 PER1 PIN1 PIN4 PKN1 PKN3 PNMA5 PNMA6A POLDIP3 POLL POLM PRKAB2 PRKCG PRKCI PRPF18 PRPF31 PSMA1 RAD51D RAPGEF3 RBM41 RPP25 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHC3 SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 SSX2IP STAMBPL1 SUV39H2 TASOR2 TCEA2 TCEANC TCL1B TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRIM73 TRPV6 TSHZ2 TSPYL4 TTC23 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 VPS9D1 WDR25 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF148 ZNF35 ZNF410 ZNF438 ZNF564 ZNF581 ZNF688
Entrez ID		57332	9240
HPRD ID		13006	04926
Ensembl ID		ENSG00000141570	ENSG00000176903
Uniprot IDs		Q9HC52	Q8ND90
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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