PTBP1 and SFPQ

Number of citations of the paper that reports this interaction (PubMedID 8449401)
162

Data Source:
HPRD (in vivo, in vitro)

		PTBP1	SFPQ
Description		polypyrimidine tract binding protein 1	splicing factor proline and glutamine rich
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Dendrite Cytoplasm Paraspeckles RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of RNA Splicing Positive Regulation Of Protein Dephosphorylation Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Activation Of Innate Immune Response Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Histone H3 Deacetylation Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
Drugs			Copper Artenimol
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lymphocyte percentage of white cells ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Endometrial cancer ( 21499250) Hip circumference ( 28552196)
Interacting Genes		103 interacting genes: APBB1 APP CALCOCO2 CASP3 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL IL7R LINC00839 LINC01554 MARK4 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NONO OGT PCBP1 PCBP2 PCBP3 PRKACA QKI RAVER1 RAVER2 RBFOX2 RBM10 SFPQ SNRPA SRPK2 SUMO2 ZMYM2	107 interacting genes: APBB1 AR CSNK2A1 ERG ESR1 EXOSC5 FHL2 FMR1 FUS FXR1 FXR2 GAS7 H3-4 JPT1 LAMTOR5 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NONO OGT PIN1 PPARG PPP1CA PRPF40A PSPC1 PTBP1 RAC1 SIN3A SMAD5 SNRPA SREK1 TCERG1 TOP1 UBC UBE2I WBP4 ZMYM2
Entrez ID		5725	6421
HPRD ID		02823	07284
Ensembl ID		ENSG00000011304	ENSG00000116560
Uniprot IDs		A0A7I2V621 P26599	A0A384N5Z8 P23246 Q86VG2
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ	4WII 4WIJ 4WIK 5WPA 6NCQ 6OWJ
Enriched GO Terms of Interacting Partners?
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