PSMD5 and CASTOR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PSMD5	CASTOR1
Description		proteasome 26S subunit, non-ATPase 5	cytosolic arginine sensor for mTORC1 subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytosol Proteasome Accessory Complex	Cytosol
	Molecular Function	Protein Binding	Protein Binding Arginine Binding Identical Protein Binding
	Biological Process	Proteasome Regulatory Particle Assembly	Regulation Of Intracellular Signal Transduction Cellular Response To L-arginine Negative Regulation Of TORC1 Signaling
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Systolic blood pressure ( 27618452)	Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)
Interacting Genes		9 interacting genes: APP BTBD1 BTBD2 CASTOR1 LNX2 PSMC1 PSMC2 PSMD2 TFCP2	5 interacting genes: CASTOR2 PSMD5 TMA16 ZC2HC1A ZC2HC1B
Entrez ID		5711	652968
HPRD ID		05121	18904
Ensembl ID		ENSG00000095261	ENSG00000239282
Uniprot IDs		Q16401	Q8WTX7
PDB IDs			5GS9 5GT7 5GT8 5GV2 5I2C
Enriched GO Terms of Interacting Partners?
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