KNL1 and PAK6

		KNL1	PAK6
Description		kinetochore scaffold 1	p21 (RAC1) activated kinase 6
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GO Annotations	Cellular Component	Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		7 interacting genes: BUB1 BUB1B DSN1 MIS12 PAK6 PPP1CA TTK	28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1
Entrez ID		57082	56924
HPRD ID		10634	06426
Ensembl ID		ENSG00000137812	ENSG00000137843
Uniprot IDs		Q8NG31	A0A024R9Q4 Q9NQU5
PDB IDs		3SI5 4A1G 4NF9 4NFA	2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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