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PSMC1 and CCDC85B
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
1103
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMC1
CCDC85B
Description
proteasome 26S subunit, ATPase 1
coiled-coil domain containing 85B
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Nucleus
Cytoplasm
Centrosome
Adherens Junction
Molecular Function
RNA Binding
Protein Binding
ATP Binding
Proteasome-activating Activity
Protein Binding
Delta-catenin Binding
Biological Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Cell Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Seasonality and depression (
30217971
)
Acne (severe) (
24927181
)
Asthma (
31959851
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
39 interacting genes:
APP
ATXN7
CCDC85B
CCND3
CNOT7
CRK
FBLN5
FKBP8
HSPB1
JMJD1C
JMJD6
KDM1A
LINC01554
LNX1
MAGEA2
MAGEA2B
MEOX2
MORF4L1
OGT
PAAF1
PAX4
PIAS3
PRKN
PSMA7
PSMC2
PSMC4
PSMC5
PSMD2
PSMD5
PSMD7
PTGER4
STMN2
SUMO2
SUV39H1
TRAF6
UBASH3A
UBLCP1
VCP
ZBTB8A
138 interacting genes:
AGGF1
AKAP17A
AKIRIN2
APEX2
AQP1
BEX2
BEX3
BIRC5
C19orf25
C21orf91
C2CD6
C7orf50
C8orf48
CARD9
CCDC112
CCDC116
CCDC120
CCDC185
CCDC33
CCNK
CDK18
CDKN1A
CENPP
CEP70
CFAP53
CHCHD3
COPS4
CWC25
DEPP1
DEUP1
DOK5
DTNB
DUSP13
EIF3H
ENKD1
EPS8
EXOC7
EXOC8
EZH2
FAM107A
FAM124B
FAM13C
FAM214B
FAM27E3
FAM50B
FAM74A4
FASTKD5
FBF1
FCHSD2
FNDC11
FXR2
GCC1
GFI1B
GPANK1
HMG20B
HNRNPC
IKZF5
INO80B
KANSL1
KIAA0408
KRT17
KRT18
KRT20
KRT6A
LDOC1
LMO3
LNX1
LZTS2
MBIP
MCM10
MCRS1
MEAF6
MOAP1
MOB1A
MOB4
NDUFA5
NEK6
NIF3L1
NRIP1
NUP54
ODAD4
PBXIP1
PIDD1
PKN1
PLEKHF2
PLOD3
POLR2L
PRC1
PRPF3
PSMA1
PSMC1
PSMC6
PSMF1
RALYL
RBM41
RBM7
RGS8
RIBC2
RNF8
SCNM1
SETD5
SF3A3
SIX1
SLU7
SMARCD1
SPATA46
SYT17
SYTL4
TASOR2
TCEANC
TCHP
TEAD4
THAP7
TNNI1
TNNT1
TSPYL4
TTC14
TUBGCP4
USP2
UTP14A
UTP6
VPS72
ZBTB16
ZBTB5
ZC2HC1C
ZFC3H1
ZFP36
ZNF165
ZNF205
ZNF250
ZNF337
ZNF417
ZNF426
ZNF564
ZNF587
ZNF638
ZNF764
ZNF821
Entrez ID
5700
11007
HPRD ID
04084
16101
Ensembl ID
ENSG00000100764
ENSG00000175602
Uniprot IDs
P62191
Q53XL8
Q15834
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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