PSMB10 and PSKH1

		PSMB10	PSKH1
Description		proteasome 20S subunit beta 10	protein serine kinase H1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex	Endoplasmic Reticulum Membrane Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Threonine-type Endopeptidase Activity Protein Binding	Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Humoral Immune Response Proteasomal Protein Catabolic Process T Cell Proliferation	Protein Phosphorylation Determination Of Left/right Symmetry Heart Development
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Carfilzomib
Diseases
GWAS		Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		12 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSKH1 PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN	6 interacting genes: CDC6 HPR PSMB10 RDH13 SNTA1 ST3GAL2
Entrez ID		5699	5681
HPRD ID		01465	01511
Ensembl ID		ENSG00000205220	ENSG00000159792
Uniprot IDs		P40306	P11801
PDB IDs		6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW
Enriched GO Terms of Interacting Partners?
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