PSMB8 and UBAP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PSMB8	UBAP2
Description		proteasome 20S subunit beta 8	ubiquitin associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex	P-body Nucleus Cytoplasm
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding	RNA Binding Protein Binding Cadherin Binding
	Biological Process	Proteasomal Protein Catabolic Process Antigen Processing And Presentation Fat Cell Differentiation Regulation Of Endopeptidase Activity	Regulation Of Gene Expression
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Interferon alpha/beta signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Carfilzomib
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) IgA nephropathy ( 32912934 25305756) Nephropathy ( 21399633)	Adult body size ( 32376654) Bipolar disorder ( 20351715) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 30054458 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		25 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID NOTCH4 PFDN5 POLR2G POMP PSMA6 PSMB10 PSMB9 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12	45 interacting genes: ASB13 ATPAF2 BANP C10orf55 CREM DAZAP2 EFHC1 FAM168B FNDC3B FOXH1 GBA2 HGS IGFN1 ISX ITCH JMJD7 KANK2 KRTAP15-1 LCK MGAT5B NOXA1 NPAS2 NUTF2 OTX1 PLAC8 PLEKHB2 PPP2CA PRSS53 PSMB8 RBPMS RHOXF2 SHC3 SPAG8 TENT5B TEP1 TEX37 TFG TLE5 TMEM8B TP53BP1 TRAPPC6A VENTX VPS37C WRAP53 ZNF34
Entrez ID		5696	55833
HPRD ID		01515	06748
Ensembl ID		ENSG00000204264	ENSG00000137073
Uniprot IDs		P28062 X5CMJ9	B4DH66 B7Z7P2 Q5T6F2 Q9P0H6
PDB IDs		5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B
Enriched GO Terms of Interacting Partners?
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