RAD18 and PDCD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAD18	PDCD5
Description		RAD18 E3 ubiquitin protein ligase	programmed cell death 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death	Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798) Triglyceride levels ( 34074324)	Blood protein levels ( 29875488) Glycated hemoglobin levels ( 34059833) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23377640) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 32888494) Red cell distribution width ( 32888494 27863252) Systemic lupus erythematosus ( 33272962)
Interacting Genes		29 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 MAGEA4 MAP3K1 MAPK8 MLKL NBN ORC2 PCGF6 PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	16 interacting genes: ACP5 CDC42 CEP126 EEF1G GGCX KAT5 KDM1A LRIF1 NUDT3 OTUD5 PICK1 RAD18 TRIM35 UBE2D3 UTP14A VHL
Entrez ID		56852	9141
HPRD ID		09242	06843
Ensembl ID		ENSG00000070950	ENSG00000105185
Uniprot IDs		Q9NS91	O14737
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0	1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?
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