NPDC1 and MADD

Number of citations of the paper that reports this interaction (PubMedID 10970871)
15

Data Source:
HPRD (two hybrid, in vitro)

		NPDC1	MADD
Description		neural proliferation, differentiation and control 1	MAP kinase activating death domain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Axon
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process		Cell Surface Receptor Signaling Pathway Activation Of Protein Kinase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Lymphocyte counts ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count ( 32888494 27863252)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: C3orf52 CCND1 CCND2 CCND3 CDK2 CPT1A CYSRT1 E2F1 EMD FHL5 HINFP HNRNPK KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP9-3 MADD MAL MDFI MS4A13 NBPF19 NOTCH2NLA PLSCR1 RBMY1F RBMY1J TFDP1	10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		56654	8567
HPRD ID		12048	04664
Ensembl ID		ENSG00000107281	ENSG00000110514
Uniprot IDs		Q9NQX5	A0A0A0MRB5 Q8WXG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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