MASP1 and FCN2

Number of citations of the paper that reports this interaction (PubMedID 12421953)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MASP1	FCN2
Description		MBL associated serine protease 1	ficolin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol	Extracellular Region Collagen Trimer Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Antigen Binding Signaling Receptor Binding Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Carbohydrate Derivative Binding Mannan Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis	Complement Activation, Lectin Pathway Opsonization Recognition Of Apoptotic Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)	Blood protein levels ( 30072576 29875488)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	2 interacting genes: MASP1 MASP2
Entrez ID		5648	2220
HPRD ID		02749	03376
Ensembl ID		ENSG00000127241	ENSG00000160339
Uniprot IDs		F8W876 P48740	Q15485
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T
Enriched GO Terms of Interacting Partners?
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