PRKX and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 10026146)
26

Data Source:
HPRD (in vivo, in vitro)

		PRKX	PRKAR1A
Description		protein kinase X-linked	protein kinase cAMP-dependent type I regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm CAMP-dependent Protein Kinase Complex	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Signal Transduction Peptidyl-serine Phosphorylation Myeloid Cell Differentiation Regulation Of Cell Adhesion Regulation Of Cell Migration Cell-substrate Adhesion Endothelial Cell Migration Protein Autophosphorylation Epithelial Tube Morphogenesis Kidney Morphogenesis Regulation Of Epithelial Cell Differentiation Involved In Kidney Development	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		PKA-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of Adenylate Cyclase ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases
GWAS		Lymphocyte counts ( 29403010) Thyroid stimulating hormone levels ( 30367059)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: NEDD4 NEDD4L PKIA PRKAR1A PRKAR2A	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		5613	5573
HPRD ID		02097	01786
Ensembl ID		ENSG00000183943	ENSG00000108946
Uniprot IDs		A0A024RBU5 P51817	B2R5T5 P10644
PDB IDs			5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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