MAPK11 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 9235954)
33

Data Source:
BioGRID (enzymatic study)

		MAPK11	SH2D1A
Description		mitogen-activated protein kinase 11	SH2 domain containing 1A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Osteoblast Differentiation Protein Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Cellular Response To Interleukin-1 Cellular Senescence Cellular Response To Virus	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Minocycline KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	33 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD244 CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		5600	4068
HPRD ID		04208	02390
Ensembl ID		ENSG00000185386	ENSG00000183918
Uniprot IDs		Q15759	O60880
PDB IDs		3GC8 3GC9 3GP0	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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