PSENEN and SLC10A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PSENEN	SLC10A2
Description		presenilin enhancer, gamma-secretase subunit	solute carrier family 10 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Enzyme Binding Endopeptidase Activator Activity	Protein Binding Bile Acid:sodium Symporter Activity
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Catalytic Activity	Sodium Ion Transport Bile Acid And Bile Salt Transport Transmembrane Transport
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation	Recycling of bile acids and salts
Drugs		E-2012	Volixibat
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) epithelial cell adhesion molecule levels ( 25147954) Esophageal cancer (alcohol interaction) ( 22960999) Gallstone disease ( 30504769) Late-onset Alzheimer's disease ( 27770636) Metabolite levels ( 23823483) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Response to quetiapine in schizophrenia ( 29503163) Serum metabolite levels ( 33031748) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: APH1A CRB3 CREB3 NCSTN PSEN1 PSEN2 SLC10A2 SLC10A6 THBD TMED10	11 interacting genes: C3orf52 C5 CCL4L2 CTXN3 EFNA5 IFITM3 NRM PSENEN TEX264 TMEM222 UPK1B
Entrez ID		55851	6555
HPRD ID		06362	03189
Ensembl ID		ENSG00000205155	ENSG00000125255
Uniprot IDs		Q9NZ42	Q12908
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X
Enriched GO Terms of Interacting Partners?
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