PKN1 and ZNF282

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		PKN1	ZNF282
Description		protein kinase N1	zinc finger protein 282
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Nucleus
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Nuclear Receptor Coactivator Activity Small GTPase Binding Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Androgen Receptor Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)	Eosinophil counts ( 32888494) Hip circumference ( 28552196)
Interacting Genes		82 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC103 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1	3 interacting genes: MAPKAPK5 PIK3CG PKN1
Entrez ID		5585	8427
HPRD ID		03019	04549
Ensembl ID		ENSG00000123143	ENSG00000170265
Uniprot IDs		Q16512	A0A090N8Y3 Q86YG2 Q9UDV7
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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