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EAPP and TNFAIP3
EAPP
TNFAIP3
Description
E2F associated phosphoprotein
TNF alpha induced protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleus
Cytoplasm
Lysosome
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Protease Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Thiol-dependent Deubiquitinase
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Kinase Binding
Identical Protein Binding
Ubiquitin Binding
Protein Self-association
Lys63-specific Deubiquitinase Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
B-1 B Cell Homeostasis
Response To Molecule Of Bacterial Origin
Regulation Of Germinal Center Formation
Negative Regulation Of Chronic Inflammatory Response
Apoptotic Process
Inflammatory Response
Cytoskeleton Organization
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cell Migration
Protein Deubiquitination
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 5 Signaling Pathway
Protein K29-linked Deubiquitination
Protein K11-linked Deubiquitination
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Bone Resorption
Negative Regulation Of Innate Immune Response
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Defense Response To Virus By Host
Negative Regulation Of Inflammatory Response
Negative Regulation Of B Cell Activation
Regulation Of Vascular Wound Healing
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Lipopolysaccharide
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tolerance Induction To Lipopolysaccharide
Establishment Of Protein Localization To Vacuole
Negative Regulation Of Osteoclast Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Cellular Protein Catabolic Process
Protein K33-linked Deubiquitination
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of CD40 Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Celiac disease (
23936387
)
Insulin-related traits (multivariate analysis) (
32002517
)
Metabolite levels (
23823483
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Cardiac Troponin-T levels (
23247143
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
)
Inflammatory skin disease (
25574825
)
Malaria (
31844061
)
Multiple sclerosis (
24076602
)
Phosphatidylcholine-ether levels (
31551469
)
Primary biliary cholangitis (
26394269
)
Psoriasis (
25903422
20953190
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
)
Rheumatoid arthritis (
24449572
32723749
30423114
23143596
24390342
20453841
20453842
17982456
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Sjögren's syndrome (
24097066
24097067
)
Systemic lupus erythematosus (
27399966
23273568
26663301
26502338
19165918
28714469
19838193
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
28314753
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Tonsillectomy (
27182965
28928442
)
Type 1 diabetes (
34127860
)
Interacting Genes
6 interacting genes:
AAR2
BYSL
TNFAIP3
TNFAIP8
UBE3A
UBQLN4
47 interacting genes:
ARRDC3
CCDC50
CHUK
EAPP
GAS8
GIT2
GSK3B
IKBKB
IKBKG
LAPTM5
LNX1
MAP3K5
OCLN
PFKL
PIBF1
RAD23A
RBCK1
RIPK1
RLIM
RNF11
RNF14
RNF168
RNF216
RNF5
SNAI1
TAX1BP1
TICAM1
TNIP1
TNIP2
TRAF1
TRAF2
TRAF6
TRIM2
TRIM23
TRIM3
TRIM5
TRIM8
UBC
UBE2D1
UBE2N
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZFAND5
Entrez ID
55837
7128
HPRD ID
12631
01857
Ensembl ID
ENSG00000129518
ENSG00000118503
Uniprot IDs
Q56P03
P21580
PDB IDs
2EQE
2EQF
2EQG
2VFJ
3DKB
3OJ3
3OJ4
3VUW
3VUX
3VUY
3ZJD
3ZJE
3ZJF
3ZJG
5LRX
5V3B
5V3P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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