PRKCA and PRKCZ

Number of citations of the paper that reports this interaction (PubMedID 10339425)
25

Data Source:
HPRD (in vivo, in vitro)

		PRKCA	PRKCZ
Description		protein kinase C alpha	protein kinase C zeta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Membrane Alphav-beta3 Integrin-PKCalpha Complex Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Vesicle Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific) Protein Serine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Phospholipase Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Protein Phosphorylation Mitotic Nuclear Membrane Disassembly Cell Adhesion Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Intracellular Signal Transduction Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Long-term Memory Positive Regulation Of Cell Population Proliferation Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Negative Regulation Of Hydrolase Activity Membrane Depolarization Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ
Drugs		Phosphatidyl serine Vitamin E Tamoxifen Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate	Tamoxifen
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Daytime nap ( 33568662) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Haemorrhoidal disease ( 33888516) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 30012220 27659466) QT interval ( 29213071 24952745 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Height ( 20881960) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		230 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FOXJ1 FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKACA PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SLC9A3R1 SLC9A3R2 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ	92 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP C5 CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GABARAP GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP1LC3B MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MARCKS MBP MTHFR NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		5578	5590
HPRD ID		01498	01504
Ensembl ID		ENSG00000154229	ENSG00000067606
Uniprot IDs		L7RSM7 P17252 Q7Z727	Q05513
PDB IDs		2ELI 3IW4 4DNL 4RA4
Enriched GO Terms of Interacting Partners?
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