PRKAR1B and DTNB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRKAR1B	DTNB
Description		protein kinase cAMP-dependent type I regulatory subunit beta	dystrobrevin beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Multivesicular Body Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Postsynaptic Density Dendrite Synapse Inhibitory Synapse
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Zinc Ion Binding
	Biological Process	Protein Phosphorylation Learning Or Memory Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP-dependent Protein Kinase Activity	Neuron Differentiation Synaptic Signaling
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 32888494 27863252)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body shape index ( 34021172) Cutaneous malignant melanoma ( 32341527) Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Height ( 18391951) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) LDL cholesterol ( 21347282) Macular thickness ( 30535121) Multiple myeloma ( 22120009 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Nevus count or cutaneous melanoma ( 32341527) Resistant hypertension ( 31545351) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Working memory ( 31598132)
Interacting Genes		77 interacting genes: AKAP1 AKAP14 AKAP7 ANKS1A BAG3 BAG6 BOD1L2 CAMSAP1 CBX8 CCDC103 CCDC187 CDC37 CDKN1A CEP19 COX5B DACH1 DTNB EEF2KMT EGFR FAM161A FAM90A1 FCHSD2 GAS2L2 GLIS2 GNL3L GOLGA1 GPKOW GUCA1A IGFN1 INPP5J KANK2 KIF5B L3MBTL2 LENG1 LNX1 MAD1L1 MBD3 MED8 MYO15B NTAQ1 NXF1 PIK3R3 POLE4 PPP1R9A PRKAA2 PRKACA PRKAR1A PRPF18 PSMG1 QRICH1 RARG RUNX1T1 SAP30BP SH2D4A SHC3 SMAD3 SMAD4 SMG9 SNW1 STK16 SYTL4 TASOR2 TEAD4 THRA TSGA10IP UACA VEZF1 WNK1 WRN ZBTB16 ZMYND19 ZNF177 ZNF329 ZNF35 ZNF410 ZNF559-ZNF177 ZNF76	62 interacting genes: ABI1 ABI2 ABI3 AMOTL2 BEGAIN CBY2 CCDC136 CCDC196 CCDC85B CCDC88B CCHCR1 CEP55 CEP63 COG6 CTBP2 DEUP1 DMD DTNBP1 FAM167A FSD2 GGA1 HMG20A INSYN1 KIF5A KIF5B KRT15 KRT27 KRT31 KRT33B KRT35 KRT38 KRT40 LURAP1 MB21D2 MTUS2 NDEL1 NUP62 PICK1 POU6F2 PPFIA1 PPFIBP2 PPP1R13B PRKAR1B PRTFDC1 SNTA1 SNTG1 SNTG2 SPZ1 SSBP3 TFIP11 TRAF2 TRIM27 TRIM37 TRIM54 TSACC TXLNA USHBP1 UTRN VCP VPS52 ZBTB9 ZRANB1
Entrez ID		5575	1838
HPRD ID		01485	09091
Ensembl ID		ENSG00000188191	ENSG00000138101
Uniprot IDs		P31321	B7Z202 B7Z6A9 E7EVB6 E9PEY4 O60941 Q1I0L3
PDB IDs		4DIN 4F9K
Enriched GO Terms of Interacting Partners?
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