ARFGAP1 and SLC6A1

Number of citations of the paper that reports this interaction (PubMedID 19020038)
21

Data Source:
BioGRID (pull down)

		ARFGAP1	SLC6A1
Description		ADP ribosylation factor GTPase activating protein 1	solute carrier family 6 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Axon Neuron Projection Neuronal Cell Body GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Gamma-aminobutyric Acid:sodium Symporter Activity Protein Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Sodium:chloride Symporter Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity	Chemical Synaptic Transmission Memory Associative Learning Response To Toxic Substance Response To Sucrose Response To Inorganic Substance Response To Lead Ion Positive Regulation Of Gamma-aminobutyric Acid Secretion Response To Purine-containing Compound Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Sodium Ion Transmembrane Transport Response To Cocaine Synapse Organization Response To Calcium Ion Gamma-aminobutyric Acid Reuptake Gamma-aminobutyric Acid Import Inorganic Anion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	Na+/Cl- dependent neurotransmitter transporters Reuptake of GABA
Drugs			Tiagabine Guvacine
Diseases
GWAS			Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Lung function ( 31902109) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		36 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC6A1 SMN1 TK1 TMED2 TRIM23	6 interacting genes: ARFGAP1 DRD2 HSF2BP HTR6 OXNAD1 STX1A
Entrez ID		55738	6529
HPRD ID		06443	00664
Ensembl ID		ENSG00000101199	ENSG00000157103
Uniprot IDs		Q53F62 Q8N6T3	A0A024R2K8 A0A2R8Y4I3 B7Z3C5 P30531
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?
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