PRKACA and GJA5

Number of citations of the paper that reports this interaction (PubMedID 10728420)
29

Data Source:
HPRD (in vivo)

		PRKACA	GJA5
Description		protein kinase cAMP-activated catalytic subunit alpha	gap junction protein alpha 5
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nuclear Speck Neuromuscular Junction Calcium Channel Complex Sperm Flagellum Dendritic Spine Plasma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base	Integral Component Of Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Cell Projection
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Manganese Ion Binding Ubiquitin Protein Ligase Binding Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Mesoderm Formation Neural Tube Closure Regulation Of Heart Rate Renal Water Homeostasis MRNA Processing Protein Phosphorylation Protein Kinase A Signaling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway High-density Lipoprotein Particle Assembly Cellular Response To Heat Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Protein Binding Regulation Of Osteoblast Differentiation Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Sperm Capacitation Modulation Of Chemical Synaptic Transmission Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Regulation Of Protein Processing Cellular Response To Glucose Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Epinephrine Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Cardiac Conduction Protein Localization To Lipid Droplet Regulation Of Bicellular Tight Junction Assembly	Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Potassium Ion Transport Cell-cell Signaling Cell Communication By Chemical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Vasomotion
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Interleukin-3, Interleukin-5 and GM-CSF signaling Ion homeostasis Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Anchoring of the basal body to the plasma membrane CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling AURKA Activation by TPX2 HDL assembly ROBO receptors bind AKAP5 Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Gap junction assembly
Drugs		Pentanal Balanol Analog 2 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate Phosphonothreonine Balanol Analog 1 3,5-Diiodotyrosine Balanol Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632 Ellagic acid Fostamatinib
Diseases
GWAS			Atrial fibrillation ( 30061737 29892015) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900) Triglyceride levels ( 34074324)
Interacting Genes		219 interacting genes: AANAT ABCA1 ACLY ADCY5 ADD1 ADD2 AKAP1 AKAP14 AKAP8L AKIP1 ANXA7 APC APOBEC3G ARFGEF3 ASIC1 ASIC3 ATF1 ATP2B1 AURKA AVPI1 BAD BCL2 BFAR BRAF CACNA1C CACNB2 CACNG2 CAD CALD1 CAMKK2 CCDC88A CCND1 CD46 CDK16 CDKN1A CETN1 CFTR CIITA CLDN3 CLTC CREB1 CREM CRK CSK CUL5 CYP3A4 DMTN DNAJC5 DOCK1 DRD1 DSP EEF2K EGFR ELL ERBB3 ESR1 ETV1 FBXW11 FOS FXYD1 GABRB3 GABRR1 GAD1 GAD2 GFAP GJA5 GJB1 GLI1 GMFB GNA13 GNMT GP1BB GRIA1 GRIA4 GRK2 GSK3A GSK3B GUSB GYS1 HAND1 HAND2 HDAC1 HDAC8 HIF1A HMGCR HMGN1 HMGN2 HNF4A HNRNPD HSP90AA1 HSPA4 HSPD1 IFNAR1 IQGAP1 IRF2 ITCH ITGA2B ITGA4 ITPKA ITPKB ITPR1 ITPR2 KCNH2 KCNJ12 KCNQ1 KDELR1 KLF1 KLHL3 LCK LCP1 LIPE LRP1 MAP2 MAP3K3 MAPT MBP MC4R MECP2 MEF2D MEP1B MGMT MIP NDRG1 NFKB1 NIN NOLC1 NOS1 NOXA1 NR3C1 NSFL1C NUP85 PARK7 PDC PDE3A PDE3B PDE4B PDE4D PDPK1 PFKFB1 PFKFB2 PHKA1 PHOX2A PKIA PKIB PLIN1 PLN POU2F1 PPP1R10 PPP1R17 PPP1R1B PPP1R8 PPP1R9B PRKAR1A PRKAR1B PRKCA PSEN1 PSMD11 PTBP1 PTPN12 PTPN13 PTPN7 PTPRR RAB8A RAF1 RALBP1 RANBP9 RANGAP1 RAP1A RAP1B RAP1GAP RASGRF1 RASGRP3 RELA RFX1 RGS10 RGS13 RGS14 RHOA RRAD RSBN1 RYR1 RYR2 SI SIK1 SIK3 SLC2A2 SLC4A4 SLC9A3R2 SNAP25 SNAPIN SNPH SPTBN1 SRC STK11 STMN1 STMN2 STUB1 SYN1 SYN2 TCF4 TH THOP1 TNP1 TNP2 TPH1 TPM4 TRIM55 TRIM63 TRIP10 UBE3A UHRF1 USP20 UTRN VASP VIM VTN WT1 YWHAZ ZNF208	34 interacting genes: AAR2 ABHD16A BLCAP C4orf3 EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MFSD5 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		5566	2702
HPRD ID		03382	08699
Ensembl ID		ENSG00000072062	ENSG00000265107
Uniprot IDs		A0A024R7J0 A8K8B9 P17612	P36382 X5D2H9
PDB IDs		2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9 4UJ1 4UJ2 4UJ9 4UJA 4UJB 4WB5 4WB6 4WB7 4WB8 5BX6 5BX7 5IZF 5IZJ 5J5X 5N23 5UZK 6BYR 6BYS 6C0U 6FRX 6NO7 6QJ7 6WJF 6WJG
Enriched GO Terms of Interacting Partners?
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