CDC42BPG and TBK1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CDC42BPG	TBK1
Description		CDC42 binding protein kinase gamma	TANK binding kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Leading Edge Centriolar Satellite	Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction	Activation Of Innate Immune Response Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Neuron Death Positive Regulation Of Xenophagy
Pathways			IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Potential therapeutics for SARS
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Gout (combined type) ( 32238385) Serum metabolite levels ( 33031748) Serum uric acid levels ( 29124443) Urate levels ( 21768215)	Amyotrophic lateral sclerosis ( 29566793 27455348) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: CDC42 RAC1 RHOQ TBK1	53 interacting genes: AGAP2 AGO2 APP ATG9A AVIL AZI2 CALCOCO2 CDC37 CDC42BPG CRTC1 CYLD HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 MAP1LC3B MARCHF9 MAVS MBP MIB2 MPP3 MTPAP NCK1 NEDD4 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SCN7A SIKE1 SMCR8 SMURF1 SOCS2 SQSTM1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TRIM27 TXLNG UBQLN2 XIAP YAF2
Entrez ID		55561	29110
HPRD ID		13013	05322
Ensembl ID		ENSG00000171219	ENSG00000183735
Uniprot IDs		Q6DT37	Q9UHD2
PDB IDs			4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU
Enriched GO Terms of Interacting Partners?
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