HEMGN and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		HEMGN	FLCN
Description		hemogen	folliculin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Midbody Cell-cell Contact Zone Mitotic Spindle
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Cell Differentiation Regulation Of Osteoblast Differentiation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Regulation Of Cytokinesis Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Energy Homeostasis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process
Pathways			Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Quantitative traits ( 19197348) Thyroid cancer (Papillary, radiation-related) ( 20350937)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		34 interacting genes: AURKA AXIN2 BCL10 BUB1 CDH1 CTBP1 CTBP2 DCC DLC1 EGFR ENO1 EP300 FBXW7 FLCN GATA1 H2AC6 HMGA1 HSPA1A KAT6A KRAS MCC MED17 MLH3 NRAS ODC1 PTPRJ SMAD4 SP100 SRC THAP11 TLR2 TRAF3 WHRN ZBTB1	11 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS TMEFF1 TSTD2
Entrez ID		55363	201163
HPRD ID		17100	06278
Ensembl ID		ENSG00000136929	ENSG00000154803
Uniprot IDs		A0A024R162 Q9BXL5	A0A0S2Z5Y7 Q8NFG4
PDB IDs			3V42 6NZD 6ULG
Enriched GO Terms of Interacting Partners?
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