PBRM1 and PTS

Number of citations of the paper that reports this interaction (PubMedID 11591653)
42

Data Source:
HPRD (in vivo)

		PBRM1	PTS
Description		polybromo 1	6-pyruvoyltetrahydropterin synthase
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleoplasm RSC-type Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Cell Population Proliferation	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Mycophenolate mofetil Biopterin
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte counts ( 32888494) Major mood disorders ( 20081856) Red cell distribution width ( 32888494) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)
Interacting Genes		22 interacting genes: AMIGO3 APP B4GALT7 CCRL2 CELSR3 FBXW8 FDX1 H2AC20 H2BC21 H3C1 H4C1 HSD17B7 PCBP4 PTEN PTS RFX3 SMARCA4 SS18L2 SUMO2 TMIE ZDHHC17 ZNF512B	13 interacting genes: AP2M1 ATM COIL DDIT4L DDX10 FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10
Entrez ID		55193	5805
HPRD ID		07302	11840
Ensembl ID		ENSG00000163939	ENSG00000150787
Uniprot IDs		Q86U86	Q03393
PDB IDs		2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4	3I2B
Enriched GO Terms of Interacting Partners?
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