PPP2R1A and SLC6A2

Number of citations of the paper that reports this interaction (PubMedID 15963952)
17

Data Source:
HPRD (in vivo)

		PPP2R1A	SLC6A2
Description		protein phosphatase 2 scaffold subunit Aalpha	solute carrier family 6 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Dendrite Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Membrane Raft
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Heterodimerization Activity Protein Antigen Binding	Actin Binding Neurotransmitter Transmembrane Transporter Activity Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Chromosome Segregation RNA Splicing Response To Organic Substance Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation Regulation Of Catalytic Activity Protein-containing Complex Assembly	Neurotransmitter Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoamine Transport Norepinephrine Transport Sodium Ion Transmembrane Transport Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Neuron Cellular Homeostasis
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Initiation of Nuclear Envelope (NE) Reformation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition AURKA Activation by TPX2 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Amphetamine Phentermine Tramadol Guanadrel Reboxetine Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Methylphenidate Meperidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Cyclobenzaprine Maprotiline Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra sinica root Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Metamfetamine Phendimetrazine Nomifensine Amineptine Debrisoquine Bicifadine Milnacipran XEN2174 DDP-225 CRx-119 Amitifadine Mianserin Tesofensine Tapentadol Trodusquemine Desvenlafaxine Dexmethylphenidate Levomilnacipran Vortioxetine Dosulepin Viloxazine Zotepine Dasotraline Netarsudil Solriamfetol
Diseases
GWAS			Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		59 interacting genes: AIMP2 AKT1 AMOTL2 ARIH2 CARD11 CARHSP1 CDC42 CDK1 CSDC2 CSNK2B DAPK1 DELEC1 DUX4 EEF2 ESR1 FBXO43 GNA12 GOLGA6A GOLGA8F GRIN1 GRIN2D HSF2 HSPD1 IPO9 LINC01554 MAP3K7 MAPK6 MCM3 OGT PARK7 PLAAT3 PPP2CA PPP2R2A PPP2R3B PPP2R5A PPP2R5B PPP2R5D PPP4C PPP5C PRDX1 PRDX2 PRRG2 PTPA RAB11A RAB18 RAB7A RAP1A RORC SGO1 SGO2 SLC6A2 SMAD2 SMAD3 STRN STRN3 SUMO2 TAB1 TRADD ZFYVE9	3 interacting genes: PPP2R1A RPGRIP1L STX1A
Entrez ID		5518	6530
HPRD ID		16184	01232
Ensembl ID		ENSG00000105568	ENSG00000103546
Uniprot IDs		A8K7B7 P30153	A0A024R6T9 H3BRE9 P23975
PDB IDs		1B3U 2IE3 2IE4 2NPP 2NYL 2NYM 2PKG 3C5W 3DW8 3K7V 3K7W 4I5L 4I5N 4LAC 5W0W 6IUR 6NTS 7CUN
Enriched GO Terms of Interacting Partners?
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