PPP2CB and RAF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PPP2CB	RAF1
Description		protein phosphatase 2 catalytic subunit beta	Raf-1 proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck Pseudopodium
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Tau Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Enzyme Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Peptidyl-serine Dephosphorylation Positive Regulation Of Microtubule Binding	MAPK Cascade Response To Hypoxia Protein Phosphorylation Apoptotic Process Signal Transduction Activation Of Adenylate Cyclase Activity Heart Development Negative Regulation Of Cell Population Proliferation Cell Differentiation Thyroid Gland Development Regulation Of Cyclase Activity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Population Maintenance Regulation Of Rho Protein Signal Transduction Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Muscle Stretch Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Thymus Development Face Development Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs		Vitamin E	Sorafenib LErafAON XL281 iCo-007 Cholecystokinin Regorafenib Dabrafenib Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Asthma ( 32296059) Body shape index ( 34021172) Cardiac hypertrophy ( 21348951) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 24097068 20686565) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Total cholesterol levels ( 28334899) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		44 interacting genes: ACP5 AURKA AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR FGFR1 GAD1 GSTA1 HK3 ICOSLG KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLAT PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B ZFP28 ZNF775	160 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 EGFR EPHA2 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HERC1 HGF HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 ITCH JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LOX LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MBP MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TSC22D3 UBE2D2 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1
Entrez ID		5516	5894
HPRD ID		01487	01265
Ensembl ID		ENSG00000104695	ENSG00000132155
Uniprot IDs		A0A140VJS0 P62714	A0A0S2Z4L5 L7RRS6 P04049
PDB IDs			1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL 6NTC 6NTD 6PTS 6PTW 6VJJ 6XGU 6XGV 6XHA 6XHB 6XI7 7JHP
Enriched GO Terms of Interacting Partners?
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