PLEKHB2 and STAM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		PLEKHB2	STAM2
Description		pleckstrin homology domain containing B2	signal transducing adaptor molecule 2
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GO Annotations	Cellular Component	Integral Component Of Membrane Recycling Endosome Membrane	Nucleoplasm Cytoplasm Cytosol Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Regulation Of Cell Differentiation	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly
Pathways			EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		52 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFC1 CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 GPR45 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NRGN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A	38 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		55041	10254
HPRD ID		15144	05876
Ensembl ID		ENSG00000115762	ENSG00000115145
Uniprot IDs		A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7	O75886
PDB IDs		3AJ4 3VIA	1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?
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