PPP1CA and RB1

Number of citations of the paper that reports this interaction (PubMedID 8384581)
509

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PPP1CA	RB1
Description		protein phosphatase 1 catalytic subunit alpha	RB transcriptional corepressor 1
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Spindle Cytosol SWI/SNF Complex PML Body Rb-E2F Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Activity Ribonucleoprotein Complex Binding Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Response To Lead Ion Dephosphorylation Lung Development Negative Regulation Of Protein Binding Circadian Regulation Of Gene Expression Peptidyl-threonine Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Branching Morphogenesis Of An Epithelial Tube Cell Division Regulation Of Canonical Wnt Signaling Pathway Peptidyl-serine Dephosphorylation Cell-cell Adhesion Beta-catenin Destruction Complex Disassembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Aortic Valve Morphogenesis Chromatin Remodeling Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Regulation Of Cell Cycle Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cohesin Loading Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Circadian Clock	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Insulin human Insulin pork
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 28552196)	Birth weight ( 31043758 27680694) Chronic kidney disease ( 26420894) Diastolic blood pressure ( 34074324) Lymphocyte counts ( 32888494) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		164 interacting genes: AATK AKAP1 AKAP11 AKAP9 APAF1 ATP5MG AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDH1 CEP126 CEP170 CKB CLCN2 CLOCK CLTC CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MIIP MPHOSPH10 MST1R MYO16 NCAM1 NDP NEK2 NOC2L NOM1 NONO NOP53 PAK1 PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R16B PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R32 PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RELA RIF1 RORC RPRD2 SFPQ SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TUSC3 UBE2Z ULK1 VDR WBP11 WDR82 WWTR1 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827	199 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAAT BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCDC180 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDADC1 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CNTN3 CORO2A COX17 CREG1 CRYBA4 CSK CTBP1 CTSV CUX1 DGKZ DNMT1 DVL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 ESD FANCC FBP1 FBP2 FOS FRK GALNT12 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KMT5C L3MBTL1 LEF1 LIN54 LIN9 LMNA LRCH1 MAPK1 MAPK14 MAPK3 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MTRF1 MYC MYOD1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PCDHB5 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RASA1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SHC1 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 STX17 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TP53 TRAP1 TRIM27 TRIP11 TRMO UBE2I UBTF USP4 USP7 VDR XPA ZBTB16
Entrez ID		5499	5925
HPRD ID		15942	01574
Ensembl ID		ENSG00000172531	ENSG00000139687
Uniprot IDs		A0A140VJS9 P62136	A0A024RDV3 P06400
PDB IDs		3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6	1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL
Enriched GO Terms of Interacting Partners?
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