TRMT10C and MIR15A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		TRMT10C	MIR15A
Description		tRNA methyltransferase 10C, mitochondrial RNase P subunit	microRNA 15a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Extracellular Space Extracellular Exosome Extracellular Vesicle
	Molecular Function	TRNA Binding RNA Binding Protein Binding TRNA (guanine-N1-)-methyltransferase Activity TRNA (adenine-N1-)-methyltransferase Activity Identical Protein Binding TRNA (guanine(9)-N(1))-methyltransferase Activity MRNA (adenine-N1-)-methyltransferase Activity	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Mitochondrial RNA 5'-end Processing TRNA Methylation Positive Regulation Of Mitochondrial Translation MRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of NF-kappaB Transcription Factor Activity Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion rRNA processing in the mitochondrion
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Allergic disease (asthma, hay fever or eczema) ( 29083406) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		4 interacting genes: MIR15A MIRLET7A3 MT-TI OGT	73 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYNCRIP TAF15 TRA2A TRA2B TRIM71 TRMT10C UPF1 UTP20 YBX1 YBX3 ZNF346
Entrez ID		54931	406948
HPRD ID		15240
Ensembl ID		ENSG00000174173	ENSG00000283785
Uniprot IDs		Q7L0Y3
PDB IDs		5NFJ
Enriched GO Terms of Interacting Partners?
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