CHCHD3 and SAMM50

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid, proximity labelling technology)

		CHCHD3	SAMM50
Description		coiled-coil-helix-coiled-coil-helix domain containing 3	SAMM50 sorting and assembly machinery component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAM Complex Nucleus Mitochondrion Mitochondrial Inner Membrane MICOS Complex Extracellular Exosome MIB Complex	SAM Complex Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane Extracellular Exosome MIB Complex
	Molecular Function	Protein Binding Phosphatase Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Inner Mitochondrial Membrane Organization Mitochondrial Fusion Cristae Formation	Inner Mitochondrial Membrane Organization Mitochondrial Respiratory Chain Complex Assembly Cellular Protein-containing Complex Assembly Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import Cristae formation	Mitochondrial protein import Cristae formation RAC2 GTPase cycle
Drugs
Diseases
GWAS		Chronotype ( 30696823) Food allergy ( 29030101) Intercellular adhesion molecule 1 (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Smoking status (ever vs never smokers) ( 30643258) Urinary potassium excretion ( 31409800)	Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		40 interacting genes: AASS AMOTL2 ANKS1A ARMC7 BLZF1 C2CD6 CALCOCO2 CBY2 CCDC33 CCDC85B CEP72 CLPP CYSRT1 DGKI EFHC1 ENKD1 FANCL GMCL2 GOLGA2 KANK2 KRT40 KRTAP4-12 LMO1 LZTS2 NBPF19 NOTCH2NLA NTAQ1 NUDT3 NUTF2 NUTM1 PDE4DIP PPP1CB RAB3IP RPGRIP1 SAMM50 SPAG5 SSX2IP TRAF1 TRIM27 USHBP1	5 interacting genes: CHCHD3 CHCHD6 HMGB2 MEOX2 TOMM40
Entrez ID		54927	25813
HPRD ID		13044	10826
Ensembl ID		ENSG00000106554	ENSG00000100347
Uniprot IDs		A4D1N4 B7Z1X9 C9JRZ6 Q9NX63	Q9Y512
PDB IDs
Enriched GO Terms of Interacting Partners?
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