DEF8 and ZNF587

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEF8	ZNF587
Description		differentially expressed in FDCP 8 homolog	zinc finger protein 587
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus
	Molecular Function	Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Lysosome Localization Intracellular Signal Transduction Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly	Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Basal cell carcinoma ( 33549134) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Red vs. brown/black hair color ( 30531825) Squamous cell carcinoma ( 26908436 26829030)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		5 interacting genes: MEOX2 TRIM55 TRIM63 ZNF417 ZNF587	130 interacting genes: ADAMTSL4 AQP6 ASB15 ASB6 AXIN2 BEGAIN C17orf50 CARD10 CARD9 CCDC125 CCDC136 CCDC85B CEP44 CEP70 CHRDL2 CSRNP1 CYSRT1 DEF8 DHX57 EFEMP2 FCHSD2 FHL3 FHL5 FSD2 FST GOLGA2 GOLGA6L9 GOPC GSC2 HMBOX1 HOOK2 HOXA1 HSF2BP IGFBP6 IKBKG IKZF1 IKZF3 INSC ISY1-RAB43 KATNBL1 KCTD7 KPRP KRT31 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LHX3 LIMS1 LMO3 LRP2BP LZTS1 MCCD1 MDFI MEOX2 MID2 MKRN3 MTUS2 MYF5 NBPF19 NDUFB7 NEK6 NKAPL NOTCH2NLA NR1D2 PBX2 PDE4DIP PLSCR1 PNMA2 PPARA PRDM14 PRICKLE4 PRPF31 RORB RUNDC3A SMAD9 SMYD5 SOX13 SPRED1 SPRY2 SPRY3 SSX2IP STX11 TBC1D26 TCF4 TENM4 TFIP11 TMCC2 TNS2 TRAF1 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXK VPS52 VWC2 ZBTB43 ZBTB8A ZGPAT ZIM2 ZKSCAN8 ZNF286A ZNF330 ZNF417 ZNF547 ZNF774 ZNF829 ZNF837 ZRANB1
Entrez ID		54849	84914
HPRD ID		07882	15864
Ensembl ID		ENSG00000140995	ENSG00000198466
Uniprot IDs		Q6ZN54	Q96SQ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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