NDE1 and TUBG1

Number of citations of the paper that reports this interaction (PubMedID 11163258)
101

Data Source:
HPRD (in vivo)

		NDE1	TUBG1
Description		nudE neurodevelopment protein 1	tubulin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow Synapse	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Microtubule Cytoplasmic Microtubule Cell Leading Edge Ciliary Basal Body Apical Part Of Cell Recycling Endosome Non-motile Cilium Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Neuroblast Proliferation Cell Migration Cerebral Cortex Development Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Mitotic Spindle Organization Cytoplasmic Microtubule Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Vinblastine
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Mean platelet volume ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		28 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 NOMO1 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398	35 interacting genes: APP BRCA1 CENPJ CNTN2 CTRL CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OGT PCNT PHB PIK3R1 PLK1 PXN RACGAP1 RACK1 RARA RASSF1 RND2 RNF19A RPGR SGCA SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4 WNT3
Entrez ID		54820	7283
HPRD ID		14815	01853
Ensembl ID		ENSG00000072864	ENSG00000131462
Uniprot IDs		Q9NXR1 X5DP35 X5DR54	P23258
PDB IDs			1Z5V 1Z5W 3CB2 6V5V 6V6S 7AS4
Enriched GO Terms of Interacting Partners?
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