FBLIM1 and FERMT2

Number of citations of the paper that reports this interaction (PubMedID 12679033)
150

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FBLIM1	FERMT2
Description		filamin binding LIM protein 1	FERM domain containing kindlin 2
Image
GO Annotations	Cellular Component	Fibrillar Center Stress Fiber Cytoplasm Cytosol Focal Adhesion Cell Junction Cell Periphery	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Cell Cortex Cell Surface Cell Junction Cell-substrate Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Lamellipodium Membrane I Band
	Molecular Function	Protein Binding Filamin Binding Metal Ion Binding	Actin Binding Integrin Binding Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Actin Filament Binding
	Biological Process	Regulation Of Cell Shape Regulation Of Integrin Activation Cell-cell Adhesion	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Integrin Activation Positive Regulation Of Integrin Activation Adherens Junction Maintenance Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Myosin Light Chain Kinase Activity Negative Regulation Of Vascular Permeability Positive Regulation Of GTPase Activity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Focal Adhesion Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Limb Development Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Protein Localization To Cell Junction Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells
Pathways		Cell-extracellular matrix interactions	Cell-extracellular matrix interactions RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)	Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 31959993 30054594) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033 32439900) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		12 interacting genes: ADAT3 C19orf54 CUTA FERMT2 FLNA FLNB H3-5 H3C1 KAZN LMO3 SHISA6 TRIM15	8 interacting genes: APP CMTM5 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		54751	10979
HPRD ID		09669	06374
Ensembl ID		ENSG00000162458	ENSG00000073712
Uniprot IDs		Q8WUP2	A0A024R687 Q96AC1
PDB IDs		2K9U 2W0P 4P3W	2LGX 2LKO 2MSU 4F7H 6U4N 6XTJ
Enriched GO Terms of Interacting Partners?
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