PPARD and NR1H2

Number of citations of the paper that reports this interaction (PubMedID 15722453)
23

Data Source:
BioGRID (pull down)

		PPARD	NR1H2
Description		peroxisome proliferator activated receptor delta	nuclear receptor subfamily 1 group H member 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Lipid Binding NF-kappaB Binding Linoleic Acid Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Apoptotic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Population Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process Response To Glucose Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cholesterol Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Regulation Of Lipid Metabolic Process Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Wound Healing Vasodilation Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Regeneration Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Apoptotic Signaling Pathway Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid	PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs		alpha-Linolenic acid Icosapent Troglitazone Valproic acid Treprostinil Rosiglitazone Sulindac Bezafibrate Phthalic Acid Heptyl glucoside Oleic Acid cis-Vaccenic acid Elafibranor KD3010 Cardarine (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin Fenofibric acid Fish oil	GW-3965 Benzenesulfinic acid TO-901317 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL Diacerein Rhein
Diseases
GWAS		Cataracts in type 2 diabetes ( 23137000) Childhood body mass index ( 33045005) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 27863252) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		43 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NR1H2 NR1H3 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1 ZNF837	51 interacting genes: BAG6 CDKN1A CHD3 COL4A5 CSAD DNMT3L DUSP12 ERG28 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PPARA PPARD PPARG PRKCA RARA RHOU RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		5467	7376
HPRD ID		02679	02660
Ensembl ID		ENSG00000112033	ENSG00000131408
Uniprot IDs		A0A024RCW6 F1D8S7 Q03181	F1D8P7 P55055
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P	1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ 6JIO 6K9G 6K9H 6K9M 6S4N 6S4T 6S4U 6S5K
Enriched GO Terms of Interacting Partners?
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