TMEM106B and TMEM106C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM106B	TMEM106C
Description		transmembrane protein 106B	transmembrane protein 106C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Late Endosome Membrane	Cellular_component Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding ATPase Binding	Molecular_function Protein Binding
	Biological Process	Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Lysosome Localization Dendrite Morphogenesis Positive Regulation Of Hydrolase Activity Positive Regulation Of Dendrite Development Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Biological_process
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Alzheimer's disease (APOE e4 interaction) ( 25778476) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cigarettes smoked per day in Schizophrenia ( 33691233) Coronary artery disease ( 29212778 33020668) Crohn's disease ( 32581322) Depression ( 33859377 29700475) Differential aging (frontal cortex) ( 28330615) Differential aging in older adults (frontal cortex) ( 28330615) Experiencing mood swings ( 29500382) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) General factor of neuroticism ( 30867560) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Idiopathic dilated cardiomyopathy ( 29495422) Lifetime anxiety disorder ( 31748690) Liver enzyme levels (alkaline phosphatase) ( 33972514) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Plasma kynurenine levels in major depressive disorder ( 29317604) Residual cognition ( 28441426) Response to amphetamines ( 22952603) Response to taxane treatment (placlitaxel) ( 23006423) Serum alkaline phosphatase levels ( 33547301) Tourette syndrome ( 22889924) Triglycerides ( 30275531)	Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: PHF14 TMEM106C	42 interacting genes: ADAM33 AIG1 BNIP3 C14orf180 CLDN19 CMTM7 CTXN3 CXCL9 EDDM3B FAXDC2 GOSR2 HACD1 IGFBP5 JAGN1 KRT31 KRTAP10-3 MAL MARCHF2 MYADM NKG7 NRSN1 PGA4 PLN PLP1 PLPP6 PTTG1IP RPRM SEC22A SERP2 SFTPC SMAGP TMEM106A TMEM106B TMEM11 TMEM218 TMEM35A TMEM97 TSPAN33 UPK2 VAMP5 YIPF6 ZFPL1
Entrez ID		54664	79022
HPRD ID		07745	14690
Ensembl ID		ENSG00000106460	ENSG00000134291
Uniprot IDs		A0A024R9Z1 Q9NUM4	Q9BVX2
PDB IDs
Enriched GO Terms of Interacting Partners?
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