USP53 and IREB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		USP53	IREB2
Description		ubiquitin specific peptidase 53	iron responsive element binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cell-cell Junction Bicellular Tight Junction	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Action Potential Sensory Perception Of Sound Biological_process Response To Auditory Stimulus Protein Deubiquitination Neuron Apoptotic Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Post-embryonic Development Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis Intestinal Absorption Iron Ion Homeostasis
Pathways			Iron uptake and transport
Drugs
Diseases
GWAS		Body mass index ( 29273807) Body shape index ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 25241909 22080838 20173748) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 25056061 29483656)
Interacting Genes		9 interacting genes: CRK CRKL DAB1 GRB2 IREB2 NECTIN2 SAMD4B TRAF2 UBC	5 interacting genes: APP RBCK1 TERT USP53 YBX1
Entrez ID		54532	3658
HPRD ID		11669	08858
Ensembl ID		ENSG00000145390	ENSG00000136381
Uniprot IDs		Q70EK8 Q9H9I0	D3DW85 P48200
PDB IDs			6VCD
Enriched GO Terms of Interacting Partners?
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