FBXW5 and KRTAP4-12

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FBXW5	KRTAP4-12
Description		F-box and WD repeat domain containing 5	keratin associated protein 4-12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Keratin Filament
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		36 interacting genes: ADAMTSL4 CYP1A1 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	152 interacting genes: ADAM12 ADAMTSL4 ALPP AQP1 ATG12 ATN1 AXIN1 BAG4 BAHD1 BEX2 C10orf62 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CDX2 CHCHD3 CHIC2 CHRD CLCNKA CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 CYSRT1 DBF4B DLK2 EIF4E2 ELOA2 FAM107A FAM27E3 FAM76B FBXL18 FBXO34 FBXW5 FCHO1 FUCA2 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 IGSF8 ILF3 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP5-1 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NLA NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP POU4F2 PRKAB2 PRKAG1 PRR13 PTPMT1 QPRT R3HDM2 RERE RPS28 SHFL SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY1 SPRY2 TAP1 TBC1D16 TBC1D23 TGM1 THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF414 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF497 ZNF581 ZNF638 ZNF655 ZNF696 ZNF764 ZNF837 ZSCAN26
Entrez ID		54461	83755
HPRD ID		10955	13941
Ensembl ID		ENSG00000159069	ENSG00000213416
Uniprot IDs		A0A024R8H7 Q969U6	Q9BQ66
PDB IDs
Enriched GO Terms of Interacting Partners?
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