ERRFI1 and WDR61

Number of citations of the paper that reports this interaction (PubMedID 20351267)
50

Data Source:
BioGRID (two hybrid)

		ERRFI1	WDR61
Description		ERBB receptor feedback inhibitor 1	WD repeat domain 61
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Transcriptionally Active Chromatin Ski Complex
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Small GTPase Binding	Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Lung Vasculature Development Lung Epithelium Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation
Pathways			Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Hair shape ( 29220522) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Reticulocyte count ( 32888494)
Interacting Genes		60 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 FYN GAS1 GNPDA2 GRB2 GTF2H2 HYDIN IL2RG MFSD5 MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WDR61 WEE1 YWHAB ZPBP	12 interacting genes: ACVR1 BARD1 DNAJA4 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ
Entrez ID		54206	80349
HPRD ID		09218	15236
Ensembl ID		ENSG00000116285	ENSG00000140395
Uniprot IDs		B3KTV8 I6S2Y9 Q9UJM3	H0YL19 Q9GZS3
PDB IDs		2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV	3OW8 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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