CYCS and AGTPBP1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
337

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CYCS	AGTPBP1
Description		cytochrome c, somatic	ATP/GTP binding carboxypeptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Intracellular Membrane-bounded Organelle Axon Cytoplasm
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Metallocarboxypeptidase Activity Zinc Ion Binding Tubulin Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Eye Photoreceptor Cell Differentiation Proteolysis Mitochondrion Organization Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Cerebellar Purkinje Cell Differentiation Olfactory Bulb Development Central Nervous System Neuron Development Protein Deglutamylation C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation Neurotransmitter Metabolic Process Neuromuscular Process Retina Development In Camera-type Eye Anterograde Axonal Transport Of Mitochondrion Retrograde Axonal Transport Of Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1	Carboxyterminal post-translational modifications of tubulin
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	General risk tolerance (MTAG) ( 30643258)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	10 interacting genes: CBY1 CYCS DISC1 ENO1 NYNRIN PPFIA1 PPFIA4 PYGM TNIK UBC
Entrez ID		54205	23287
HPRD ID		00479	08442
Ensembl ID		ENSG00000172115	ENSG00000135049
Uniprot IDs		G4XXL9 P99999	A0A024R288 J3KNS1 Q9UPW5
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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